Generic Viagra (Sildenafil) Pills

Of the four subjects who received VIAGRA 100 mg in the first part of this study, a severe adverse event related to blood pressure effect was reported in one patient (postural hypotension that began 35 minutes after dosing with VIAGRA with symptoms lasting for 8 hours), and mild adverse events potentially related to blood pressure effects were reported in two others (dizziness, headache and fatigue at 1 hour after dosing; and dizziness, lightheadedness and nausea at 4 hours after dosing). There were no reports of syncope among these patients. For these four subjects, the placebo-subtracted mean maximum decreases from baseline in supine and standing systolic blood pressures were 14.8 mmHg and 21.5 mmHg, respectively. Two of these subjects had a standing SBP < 85mmHg. Both of these subjects were protocol violators, one due to a low baseline standing SBP, and the other due to baseline orthostatic hypotension.

In the second study, a single oral dose of VIAGRA 50 mg or matching placebo was administered in a 2-period crossover design to 20 generally healthy males with BPH. Following at least 14 consecutive days of doxazosin, VIAGRA 50mg or matching placebo was administered simultaneously with doxazosin 4 mg (17 subjects) or with doxazosin 8 mg (3 subjects). The mean subject age in this study was 63.9 years.

Twenty subjects received VIAGRA 50 mg, but only 19 subjects received matching placebo. One patient discontinued the study prematurely due to an adverse event of hypotension following dosing with VIAGRA 50 mg. This patient had been taking minoxidil, a potent vasodilator, during the study.

I am a 27-year-old male model from NY, and I have been suffering from ED since I lost my virginity at 16. I am a very good-looking male, and I can get almost any girl I want, but I was always too afraid of the embarrassment of facing a girl after 2 minutes of sex. I was tired of pleasing my girlfriend of 4 years orally. I started noticing Viagra pills laying around my father’s house, and was very curious about how they worked! I knew they had to work if my father at the age of 53 was taking them. I snuck two of his 50-mg pills, and took them home, where they laid on my dresser for 2 weeks, because I was skeptical of it actually working. After 2 weeks I finally decided to pop one of the pills 30 minutes before sex, and I was amazed at the results! After I had my daily 2-minute orgasm, I thought “Oh No, it didn’t work” and assumed my dick would go soft a minute later as usual, But it stayed ROCK HARD literally for at least 4 hours. I kept going, and going! I was having sex like I never imagined I could. I came at least two more times that night, and it never went down! My girlfriend was blown away, and begged me to stop! I never thought I would have a girl say that to me! Viagra definitely is a miracle pill. I thought I would have to deal with ED for the rest of my life. I would recommend Viagra to anyone curious enough to try it! And hopefully we will see your positive results posted on this site with the rest of ours. - Chris, Age 27, New York

It might. A surprising new area of research is whether taking a small dose of Viagra every night works as a preventative to stave off impotence, just as people can take an aspirin a day to prevent heart attack.

Though you wouldn’t think you’d get much out of Viagra while you’re sleeping, it turns out that nighttime erections — most men get three or four every night — are crucial to maintaining potency. Because most men don’t have several erections during the day, the nocturnal erection, which allows blood and oxygen to flow to the genitals, is nature’s way of keeping the penis in working order. The theory is that anything that increases the intensity and duration of nighttime erections is good for long-term potency.

But don’t you need a sexual stimulus for Viagra to work? You do, and the likely trigger for nighttime erections, rapid-eye-movement sleep, is said to be the strongest sexual stimulus a man can experience. The brain shuts down all other activity to the penis and the level of adrenaline, which interferes with erections, plummets.

An Italian study of 44 men gave half the men 50 milligrams of Viagra before they went to sleep. The men averaged 39 years of age and didn’t have erectile dysfunction. Those who took Viagra had significantly longer and more rigid nighttime erections than the men taking a placebo.

Irwin Goldstein, a noted Boston urologist, says about 400 of his patients are using 25 mg of Viagra each night as a preventative measure. “Men say, ‘I’m potent. I don’t want to become impotent. Is there something I can do?’ ” says Dr. Goldstein. “It’s a very simple strategy for preserving sexual health.”

But while it makes sense in theory, whether nighttime Viagra use can prevent impotence is far from proven. Pfizer says it’s studying whether nighttime Viagra use can help improve sexual function in patients who have had prostate surgery but it won’t present the results until early next year.

Meanwhile, it’s worth noting that the best way to prevent impotence is to keep your veins from clogging up in the first place. Don’t smoke, eat healthy foods, lose weight and lower your cholesterol.

The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). The approximately 4,000-fold selectivity for PDE5 versus PDE3 is important because PDE3 is involved in control of cardiac contractility. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels.

In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle. The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.

Because Viagra is Internationally renowned for it’s efficiency. Viagra contains Sildenafil Citrate which helps dilating blood vessels in the penis, allowing the inflow of blood needed for a longer and harder erection.
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